Astm d4275 17 standard test method for determination of. Butylhydroxytoluene european pharmacopoeia ep reference standard. Butylated hydroxy toluene 2,6ditert butyl 4methylphenol cas no. Journal of chemical and pharmaceutical research, 2017, 95. Butylated hydroxy toluene, butylhydroxytoluene, or bht is a fatsoluble organic compound in a white powder form that is primarily used as an antioxidant food additive and cosmetics and, pharmaceuticals. Butylated hydroxytoluene can be analyzed by this reverse phase rp hplc method with simple conditions. Bht was patented in 1947 and is effective and safe in a great variety of hydrocarbon products. Shop a large selection of phenylpropanes products and learn more about fisher science education butylated hydroxy toluene. Butylated hydroxytoluene c15h24o cid 31404 structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Butylhydroxytoluene cas 128370 e 321 find msds or sds, a coa, data sheets and more information. The phenolic antioxidant butylated hydroxy toluene bht causes toxic effects in experimental animals including hemorrhage, lung,liver and kidney injury, and.
Butyl hy droxyl toluene bht scientif ical ly is nam ed alph a phall ic organic com pounds, chemi call y i s a derivati ve of phenol 2, 6 ditert butyl 4m ethyl phenol. Final report on the safety assessment of bht toxicology usu. Pdf to prove there were using butylated hydroxyl toluene bht in food as an additive to conserve food, this study involved a test and. Hazards identification aquatic toxicity chronic, category 1. Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, antipyretic and analgesic activity. Butylated hydroxytoluene bht, also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its antioxidant properties. Thermal decomposition can lead to release of irritating gases and vapors. Solubility of butylated hydroxytoluene bht in aqueous and alcohol solutions from 293. Material safety data sheet butylated hydroxytoluene bht sc204659 hazard alert code key. Butylated hydroxy toluene bht is a manufactured antioxidant preservative commonly used in plastics, rubber, petroleum products, foods, pharmaceuticals, and cosmetics. Pdf a computeraided predictions of antioxidant activities were. Combinations of antioxidants are generally used in the food product.
Bha in commercial use consists of a mixture of 3tert butyl 4hydroxyanisole 3bha and 2tert butyl 4hydroxyanisole 2bha. Product and company identification butylated hydroxy toluene synonymsgeneral names. Other inhibitors used to stabilize mma include butylated hydroxy toluene bht, phenothiazine, methylene blue, hydroxy diphenylamine and dibetanapthol 2. Solubility of butylated hydroxytoluene bht scipress. Tertiary butyl hydroquinone is a synthetic food grade antioxidant, used to stabilize foods, fats and vegetable oils against oxidative deterioration and thus extending their storage life.
Combustion products may include carbon oxides or other toxic vapors. This standard replaces gbt 178141999 feeds butyl hydroxy anisole, dibutyl hydroxy toluene and ethoxyquin determination. The source is also providing more information like the publication year, authors and more. C15h24o, cch332ch3c6h2oh, butylhydroxytoluene, butylated hydroxy toluene, pcresol, 2, 6ditert butyl, p cresol, 2, 6ditert butyl. Therefore, analytical method which is capable to measure the antioxidants simultaneously, is.
Butylated hydroxytoluene contains not less than 99. Bht crystalline is intended for use as an antioxidant additive e321 in food industry to improve the quality of edible oils, fats, to protect against oxidation of polymers in contact with food. Solubility of butylated hydroxytoluene bht in aqueous and. By itself, bht exhibited activity only in the test on analgesia. Standard name changed to feed butylhydroxyanisole, butylated hydroxytoluene, ethoxyquin, propyl gallate and determination. Mar 06, 2021 tertiary butylhydroquinone, tbhq is a synthetic food grade antioxidant, that is used to stabalize foods, fats and vegetable oils.
Parameter unit requirement appearance na white crystalsflakes assay % 99 min. Fisher science education butylated hydroxy toluene fisher. Butylated hydroxy toluene is a fat soluble synthetic antioxidant, which is primarily used as food additive because of its ability to preserve fats. These products are easy to cook with and can be added to a balanced diet. Butylated hydroxytoluene bht santa cruz biotechnology. Pdf detection and determination of butylated hydroxyl toluene.
Firstaid measures eyes in case of eye contact, rinse with plenty of water for at least 15 minutes and seek medical attention. Although it is considered safe for human health at authorized levels, its ubiquitous presence and the controversial toxicological data reported are. The bioactivation of bht to a pneumotoxic intermediate proceeds through the oxidation of one of the two equivalent t butyl groups to form 6t butyl 2 hydroxy t butyl 4methylphenol, which is subsequently oxidized to a hydroxylated quinone methide figure 2 bolton and thompson 1991. Butylated hydroxy toluene an overview sciencedirect topics. Butylated hydroxytoluene pharmaceutical secondary standard. Butyl hydroxy toluene antagonizes the gastric toxicity but. Inhalation move casualty to fresh air and keep at rest. Butylated hydroxytoluene united states pharmacopeia usp. Bht is soluble in organic solvents such as ethanol, dmso. Butylated hydroxytoluene bht is a phenolic antioxidant and free radical scavenger. Effects of ditertio butyl hydroxy toluene bht, added to the ration in increasing concentration, on the appetite and live weight of the adult male rat.
It is soluble in food oils and fats, and has good solubility in linseed oil merck index, 1989, 57 pbc, 2002. Butylated hydroxytoluene is an additive used as an antioxidant in foods, such as packet cake mixes, potato crisps, salted peanuts, and dehydrated mashed potatoes. Chemical names 2,6ditertiary butyl pcresol, 4methyl2,6ditertiary butyl phenol c. Butylated hydroxytoluene bht crops agricultural marketing. Bha is insoluble in water, but is soluble in fats, oils, propylene glycol, petroleum ether, chloroform, and 50% alcohol. Butylated hydroxy toluene created by global safety management, inc. The mechanisms of inhibition are subtle and complicated. Find more compounds similar to butylated hydroxytoluene note. Bht butylated hydroxytoluene is a substituted toluene used as an antioxidant.
Physical and chemical properties of bha are listed in the following table. Choulis, in side effects of drugs annual, 2012 butylated hydroxytoluene. Butylated hydroxytoluene an overview sciencedirect topics. Butylated hydroxytoluene, granular, nf 128370 b1196. Solubility of butylated hydroxytoluene bht in aqueous. Relevant identified uses of the substance or mixture and uses advised against. Packaging and storage preserve in wellclosed containers. Butylated hydroxytoluene bht is an antioxidant added to plastics such as polyethylene and polypropylene films and polybags to prevent aging.
Antioxidants are food additives in oil and fat products usually to decrease the process of rancidity by preventing the oxidation such as in margarine. The mobile phase contains an acetonitrile mecn, water, and phosphoric acid. Learn more about butylated hydroxytoluene bht uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain butylated hydroxytoluene bht. Chemeo is only indexing the data, follow the source links to retrieve the latest data.
Butylhydroxytoluene european pharmacopoeia ep reference. The biliary metabolism of butylated hydroxytoluene 3, 5. Butylated hydroxytoluene 99 %, fcc, fg 128370 sigma. Identification of the substancepreparation and of the companyundertaking bht butylated hydroxytoluene.
Butyl hydroxy toluene butylated hydroxy toluene, butylhydroxytoluene, or bht is a fatsoluble organic compound in a white powder form that is primarily used as an antioxidant food additive and cosmetics and, pharmaceuticals. Butylated hydroxytoluene bht is a synthetic antioxidant that is widely used as an additive in foodstuffs to prevent spoiling. Safety data sheet according to 29cfr19101200 and ghs rev. For research use only, not for human or veterinary use 1. Pdf detection and determination of butylated hydroxyl. Bht 23 table2 usesofbhtincosmeticscontinued formulationsincategoryformulationswithingredientconcentrationofuse productcategory fda1998 fda1998 ctfa1999a,1999b. In march 1990 the danish product register listed 440 products containing butylated hydroxytoluene. Bha, bht, propyl gallate, and tbhq are commonly used antioxidants. The clp regulation makes sure that the hazards presented by chemicals are clearly communicated to. This standard compared with gbt 178141999 main changes are as follows. Butylated hydroxy toluene created by global safety management, 184355161. A petition was filed with the nosb to use butylated hydroxytoluene bht as an antioxidant in a number of pheromone. Butylated hydroxy toluene 15 100 128370 2048814 c h 24 o 220. If you need tbhq, please email us, we will provide.
Butylated hydroxy toluene, 128370, laboratory chemicals, c15h24o by loba chemie, india. Tertiary butylhydroquinone tbhq tert butylhydroquinone. The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. Butylated hydroxytoluene bht, also known as dibutylhydroxytoluene, is a lipophilic organic compound, chemically a derivative of phenol, that is useful for its. Sigmaaldrich offers a number of butylated hydroxytoluene products. In 2016, by dpph method and using ascorbic acid as reference molecule, khalida alazawi evaluated the antioxidant powers of four synthetic compounds including two 2methyl3 pyrrolidin2ylideneamino quinazolin4 3h one and 3,3 1,4. Butylated hydroxytoluene united states pharmacopeia usp reference standard. Technical applications include additives in jet fuels, rubber, petroleum products, electrical transformer oil, and embalming fluid. Cooh after parenteral administration has been examined in the rat and compared to that of 3, 5. It is the most prevalent and approved antioxidant in the world.
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